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Welcome to MAGIC Online
MAGIC (Multisource Association of Genes by Integration of Clusters) can be used to integrate gene interaction data from various sources into a single prediction of the probability of functional relationship between a given pair of genes. Using MAGIC through this online interface is easy:- First Step: Organisms
The first step in using MAGIC is to ensure that the organism being studied exists in the MAGIC database. You can examine the existing organisms (including the list of genes loaded for each organism) on the Organisms page. Note that multiple versions of the same organism (with the same scientific name) may be loaded, as different subsets of genes and different sequences (important for indexed data files) may be used. If there is no applicable organism in the list, you can add one by following the instructions on the Organisms page.
- Second Step: Networks
The second step is to make sure that the Bayesian network (in Genie .DSL format) you would like to use is loaded. The list of all loaded networks, with descriptions, is available on the Networks page. Most commonly, the standard MAGIC network will be used, but test networks, networks with different parameters, etc. can be used as well. If the network you would like to use is not listed on the networks page, you can upload your own network following the instructions on the Networks page. MAGIC will parse and process your network, and save it online for later use.
- Third Step: Data Sets
The third step is to add your data to the database by making it part of a data set. Data sets for MAGIC are specific to a single organism-network pair, so you'll need to select the organism and network to which the data will apply. Then, after providing specifics about the data set, follow the instructions to finish adding your data.
- Fourth Step: Run Magic
Once the data set that you want to use is set up, MAGIC can be run and results obtained. After selecting an organism and network, a list of applicable datasets will be shown. You can select the appropriate data set from this list, and then run MAGIC. Options for execution and output are described in detail on the Run Magic page.
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